Broken heart

A broken heart (also known as a heartbreak or heartache) is a common metaphor for the intense emotional -- and sometimes physical -- stress or pain one feels at experiencing great longing. The concept is cross-cultural; most often, though not exclusively, cited with reference to a desired or lost lover; and dates back at least 3,000 years.

Emotional pain that is severe can cause 'broken heart syndrome', including physical damage to the heart.

https://en.wikipedia.org/wiki/Broken_heart